There is a widely held view that a defect in fat oxidation due to reduced mitochondrial function, or content – is present in obese adults and may predispose to weight gain and regain. The factors responsible for weight regain are not clear.Ī number of mechanisms have been proposed including changes in metabolism, appetite and energy expenditure favoring fat storage, food intake, and positive energy balance respectively. Weight lost over 3–6 months is often regained in 1–3 years, with over half of the lost weight being regained over the first 6 months. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īlthough a number of effective weight loss strategies are available –, the major challenge in obesity treatment is in preventing lost weight from being regained. The study was further supported by the NIH/NCRR Colorado CTSI Grant: UL 1 RR025780 and the Colorado Nutrition Obesity Research Center: P30DK048520. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: DHB received support from the National Institutes of Health through K24DK002935.
Received: NovemAccepted: MaPublished: April 8, 2014Ĭopyright: © 2014 Bergouignan et al. PLoS ONE 9(4):Įditor: Cedric Moro, INSERM/UMR 1048, France Citation: Bergouignan A, Kealey EH, Schmidt SL, Jackman MR, Bessesen DH (2014) Twenty-Four Hour Total and Dietary Fat Oxidation in Lean, Obese and Reduced-Obese Adults with and without a Bout of Exercise.
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